New product

Release

Tigecycline, an important antimicrobial agent for treating infections caused by carbapenem‑resistant strains, holds significant clinical value. However, tigecycline exhibits relatively reactive physicochemical properties and contains polyphenolic groups, making it susceptible to environmental factors such as light and air. Whether in culture media or in broth–agar systems, it is readily subject to dissolution and oxidation, which can lead to false‑negative susceptibility results in in vitro antimicrobial susceptibility testing.

Studies have shown that when laboratories use automated instruments or the disk diffusion method to determine bacterial susceptibility to tigecycline, false intermediate or resistant results may occur. These findings should be confirmed by standard broth microdilution or the tigecycline MTS assay (with susceptible results reported directly). However, because most laboratories lack the capacity to perform standard broth microdilution and because tigecycline MTS strips are relatively expensive, routine confirmation of “intermediate” or “resistant” isolates is often impractical. Currently, it is recommended to use a tigecycline disk‑addition method with a resuscitation solution to re‑evaluate isolates that appear intermediate or resistant on automated systems or conventional disk diffusion assays.

—Excerpted from the Technical Protocol of the CHINET China Antimicrobial Resistance Surveillance Network (2020 Edition)

Dier has launched a new product—Tigecycline Re‑sensitization Solution—which can eliminate the influence of interfering factors in antimicrobial susceptibility testing, restore tigecycline’s antibacterial activity, maintain the assay reaction conditions, and ensure tigecycline’s stability across different environments.

Product Advantages:

(1) Easy to operate

Ready-to-use reagent; simply open the cap and use.

(2) Compact size, with only 0.5 mL per vial.

A single tigecycline susceptibility disk assay requires only 6 μL of buffer; a 0.5 mL vial can be used for more than 80 tests, ensuring both the efficacy of the buffer and the feasibility of multiple assays.

(3) Good stability

It exhibits no inhibitory activity against bacteria and can stably maintain the restoration of activity against tigecycline.